What is beta-2 microglobulin test used for?
A beta-2 microglobulin tumor marker test is most often given to people who have been diagnosed with certain cancers of the bone marrow or blood. The test may be used to: Figure out the severity of cancer and whether it has spread. This process is known as cancer staging.
What causes elevated beta-2 microglobulin?
Significantly elevated levels of beta2 microglobulin can be found in lymphoproliferative disorders such as monoclonal gammopathies of immunoglobulin G (IgG) (multiple myeloma), malignant lymphomas, and chronic lymphocytic leukemia. Values have been shown to correlate with prognosis.
Where is b2 microglobulin found?
Beta-2 microglobulin
| Gene location (Human) | ||
|---|---|---|
| Chr. | Chromosome 15 (human) | |
| Band | 15q21.1 | Start |
| End |
What does beta blood test mean?
Beta-hCG (β-hCG) is a test that measures the amount of human chorionic gonadotropin (hCG) in the blood. This hormone is produced as soon as 10 days post-conception and an above-normal level can confirm pregnancy.
What is a normal beta-2 microglobulin?
The laboratory range for normal serum beta 2 microglobulin values was 1.1 to 2.4 mg/L. Patients without documented testicular tumors had values ranging from 1.4 to 9.7 mg/L. Values for normal controls ranged from 1.7 to 2.4 mg/L.
What is beta-2 microglobulin amyloidosis?
Beta-2 ̶ microglobulin (beta-2m) amyloidosis is a disabling condition that affects patients undergoing long-term hemodialysis (HD) or continuous ambulatory peritoneal dialysis (CAPD). Case reports involving patients with near ̶ end-stage renal disease also exist.
Can you diagnose multiple myeloma without a bone marrow biopsy?
Bone marrow biopsies are necessary because they provide the only direct access to tumor cells for examination. Such biopsies do not always present an accurate sample of what is occurring elsewhere in the marrow; myeloma is patchy and is not distributed evenly throughout the bone marrow.
What does it mean when beta globulin is high?
Increased beta globulin proteins may indicate: A disorder in which the body has problems breaking down fats (for example, hyperlipoproteinemia, familial hypercholesterolemia) Estrogen therapy.