What is a good HER2 score?
Testing for HER2 status The IHC gives a score of 0 to 3+ that measures the amount of HER2 proteins on the surface of cells in a breast cancer tissue sample. If the score is 0 to 1+, it’s considered HER2-negative. If the score is 2+, it’s considered borderline. A score of 3+ is considered HER2-positive.
Which has better prognosis HER2-positive or negative?
HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast. It is at least two times more likely to return than HER2-negative tumors.
What does HER2/neu status indicate?
HER2 is the more common name for the gene called ERBB2. HER2 (or HER2/neu) stands for human epidermal growth factor receptor 2. The job of HER2 is to control a protein on the surface of cells that helps them grow….What the results mean.
| Scale | Meaning |
|---|---|
| 3+ | The HER2 is higher than normal. The tumour is HER2 positive. |
What is worse triple negative or HER2-positive?
Conclusions: The triple negative subtype has the worst survival regardless of stage. HER2-positive cancers are heterogeneous and not all have poor survival. ER and PR must be considered. ER status appears to influence 5-year survival more than HER2 status.
What does HER2/neu negative mean?
Listen to pronunciation. (… NEH-guh-tiv) Describes cells that have a small amount or none of a protein called HER2 on their surface.
What does neu positive mean?
If your cancer is HER2/neu positive, you may respond to a specific medicine that targets HER2/neu receptors. Results for IHC: A score of 0 or +1 means your tumor is HER2 negative. A score of +2 means the results are unclear and FISH testing should be done. A score of +3 means the tumor is HER2 positive.
What is HER2/neu negative?
What does a HER2/neu score of 0 mean?
A score of 0 or +1 means your tumor is HER2 negative. A score of +2 means the results are unclear and FISH testing should be done. A score of +3 means the tumor is HER2 positive. FISH results are positive or negative. If you are having the blood test, HER2/neu is measured in nanograms per milliliter (ng/mL).
What are the results of HER2 testing?
The results of HER2 testing will guide you and your cancer care team in making the best treatment decisions. It is not clear if one test is more accurate than the other, but FISH is more expensive and takes longer to get the results. Often the IHC test is done first.
Is HER2/neu expression prognostic for gastric cancer?
Controversy still exists on prognostic value of HER2/neu expression and its relationship with clinicopathological characteristics and survival of gastric cancer patie … Objective: Gastric cancer is one of the oncological challenges, and tendency toward target therapy in this cancer has been increased.
What is HER2/neu protein and why is it important?
Some cancers, especially invasive breast cancers, have more HER2/neu protein than normal. About 20% of breast cancers have high numbers of these proteins on their cell surfaces.